NAD+
What Is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a molecule naturally found in every cell of the body. It plays an essential role in energy production, cellular repair, and metabolic function. As NAD+ levels naturally decline with age and stress, some people notice changes in energy, focus, recovery, and overall resilience.
NAD+ therapies are designed to support these cellular processes and promote healthy aging from the inside out.
Who Might Be Interested in NAD+?
NAD+ is commonly explored by adults looking to support energy levels, mental clarity, recovery, and long-term wellness. It is often discussed in the context of anti-aging, longevity, and metabolic health, especially by those noticing shifts in stamina, focus, or recovery over time.
Forms of NAD+
NAD+ support is available in several forms, each with different delivery methods and use cases:
Oral supplements: Taken daily to support the body’s natural production of NAD+ over time
Injectable NAD+: Administered under medical guidance, often on a weekly or scheduled basis
IV NAD+: Delivered in a clinical setting for higher-dose protocols
Nasal NAD+: A non-invasive option designed for absorption through the nasal passages, often used for convenience or as part of a maintenance routine
The form selected often depends on individual goals, access, and provider recommendations.
Dosing Schedules
Dosing schedules vary based on the form of NAD+ used and individual needs. Oral and nasal forms are often used daily, while injectable or IV options may follow weekly or monthly protocols. Plans are typically personalized and adjusted based on response and tolerance.
Safety and History
NAD+ has been studied for decades due to its critical role in cellular health. Therapies designed to support NAD+ levels are generally well tolerated when used appropriately and under professional guidance. As with any wellness or medical therapy, NAD+ is not appropriate for everyone, and individual evaluation is important when considering use.
Possible Side Effects of NAD+
Most people tolerate NAD+ well, especially at lower doses and with gradual dosing schedules. When side effects occur, they are usually mild and temporary.
Commonly reported side effects may include:
Headache or lightheadedness, particularly when starting or increasing doses
Flushing or a warm sensation, more common with injectable or IV forms
Nausea or stomach discomfort, especially with oral forms
Fatigue or brain fog, sometimes noted early as the body adjusts
Sleep changes, including vivid dreams or difficulty falling asleep
Is NAD+ a Prescription?
NAD+ availability depends on the form being used.
Some oral NAD+ supplements and NAD+ precursors are available over the counter and do not require a prescription. These are typically used for general wellness support.
Nasal, injectable, and IV NAD+ are usually provided through medical or wellness clinics and may require a prescription or medical authorization, depending on the formulation, dose, and state regulations.
Because NAD+ can be delivered in different ways and at varying doses, access and oversight requirements can vary. Consulting with a qualified healthcare provider helps determine which form is appropriate and whether a prescription is required.
Who Should Avoid NAD+ or Use Caution
NAD+ therapies are not appropriate for everyone. Certain individuals should avoid use or proceed only with medical guidance:
Pregnant or breastfeeding individuals, as safety data in these populations is limited
People with active cancer or undergoing cancer treatment, unless specifically cleared by their oncology team
Individuals with chronic liver or kidney disease, where metabolism and clearance may be affected
Those with a history of sensitivity or adverse reactions to injectable or nasal therapies
People taking medications that affect cellular metabolism or methylation, where additional monitoring may be needed
Because NAD+ can influence cellular energy and metabolic processes, professional oversight is important to determine whether it is appropriate based on health history and current medications.