GLP1s
What Are GLP-1 Medications?
GLP-1 medications are a class of therapies that help regulate appetite, blood sugar, and metabolism. They work by mimicking a natural hormone in the body called GLP-1 (glucagon-like peptide-1), which signals fullness to the brain, slows digestion, and helps the body manage insulin more effectively.
For many people, this results in feeling satisfied with smaller portions, fewer cravings, and more stable energy throughout the day.
Who Might Be Interested in GLP-1s?
GLP-1 medications are commonly explored by adults who struggle with weight management, blood sugar control, or metabolic health despite consistent efforts with diet and lifestyle changes. They may also be considered by individuals looking for additional medical support alongside nutrition, movement, and long-term wellness strategies.
Safety and History
GLP-1 medications are not new. They have been used in clinical practice since the mid-2000s, originally for the treatment of type 2 diabetes. Over time, large clinical trials and real-world use showed additional benefits related to weight loss and metabolic health, leading to expanded approvals and broader use.
Like all prescription therapies, GLP-1s have potential side effects and are not appropriate for everyone. Ongoing medical oversight and individualized decision-making are essential when considering whether these medications are a good fit.
Ways GLP-1 Medications Are Available
There are two main ways GLP-1 medications are accessed: branded medications and compounded medications. Both require a prescription, but they differ in how they are made, priced, and obtained.
Branded GLP-1 Medications
Branded GLP-1s are the FDA-approved name-brand medications you may see advertised or prescribed through traditional clinics and pharmacies. These medications are manufactured by large pharmaceutical companies and are dispensed at retail pharmacies.
They follow standardized dosing and have been studied extensively in large clinical trials. Cost and insurance coverage can vary, and access may depend on availability and plan coverage.
Compounded GLP-1 Medications
Compounded GLP-1s are prepared by licensed compounding pharmacies using the same active medication but in customized doses. They are often used when branded options are unavailable, not covered by insurance, or not a good fit for a patient’s needs.
Compounded medications are prescribed by a licensed provider and filled by regulated pharmacies that follow state and federal guidelines.
Which Option Is Right?
Both options have benefits and considerations. The best choice depends on individual health history, access, cost, and personal preferences. Understanding the differences helps patients have more informed conversations with their healthcare provider.
Common GLP-1 Medications
Semaglutide
Semaglutide is a GLP-1 medication that works by reducing appetite, slowing digestion, and helping regulate blood sugar. It has been widely used for years and is often chosen for its well-studied safety profile and consistent results when combined with lifestyle changes.
Tirzepatide
Tirzepatide is a newer medication that works on two hormone pathways involved in appetite and blood sugar regulation. This dual action may lead to greater appetite control and weight loss for some individuals, though response and tolerability can vary.
Both medications require a prescription, are typically taken once weekly, and are used alongside nutrition, movement, and long-term behavior changes.